General impact 16

GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5 GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PP…

Why it matters

The timing matters: quintuple is converging with shifts in agonism, which could amplify the downstream impact.

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